Dawn raids were held in Crystal Palace and across London and Kent this week.
Addresses including Sylvan Hill in Crystal Palace, and properties in Enfield, Southall, Tonbridge and Islington were searched in the early hours of Wednesday, January 8.
Five people aged between 25 and 40 were arrested and taken into custody.
The warrants come after two days of raids last month before Christmas, targeting those involved in West End drug dealing.
Detective Superintendent Nick Sumner said: “This operation is a continued campaign to arrest and charge those involved in bringing and selling drugs in the Soho and Cambridge Circus area.”