The shut-down Tesco in Elephant and Castle shopping centre is now home to free community events space.
Tesco Metro announced it had permanently closed in April, after struggling to fix a mouse infestation for several weeks.
The News understands the outbreak was isolated, and has been subsequently resolved.
Open from Monday, June 24, the first floor unit previously used by Tesco staff will host free fitness classes, arts and crafts workshops, and activities for the over-60s.
Diana Barranco, community director, Elephant and Castle Town Centre, said: “We have been working very hard to re-think how we can use the former Tesco store.
“We want to provide a place to bring people together through a variety of free activities for all, and the community hub provides the perfect space to do this.
“We are excited we can use it for great initiatives in the area that need it, and welcome other organisations to get in touch if they would like to hold an activity in the hub and be part of the timetable.
“We look forward to welcoming as many people from the community as possible.”
The Elephant and Castle community hub will be open Monday to Friday, at unit 227-230 on the first floor, opposite Jenny’s Burgers.
For more information, and timetables visit www.elephantandcastle.org.uk/communityhub or the Facebook page @elephantandcastleshoppingcentre