Morecambe Street in Walworth will now be closed at drop off and pick times during school days to improve road safety.
The road outside Robert Browning Primary will be closed from 8.30-9.30am and 3-4pm from Monday to Friday.
Head teacher Sarah Manley said: “The main entrance for children and parents is located on Morecambe Street, this is a narrow road that can be very busy, due to its proximity to East Street Market.
“We hope that the road closure will help to make our street safer.
“We also hope that it will encourage healthier habits, with more children walking, scooting and cycling to school.
“Parents have already welcomed the scheme and we look forward to seeing the impact of it.’
Councillor Richard Livingstone, cabinet member for environment, transport management and air quality, said the scheme would also help cut down on toxic air pollution.
“Our council is passionate about improving air quality in Southwark and this School Streets road closure will help us to reduce air pollution, improve health and increase safety and physical activity for children here at Robert Browning Primary School,” he said.